The old saying "we now know all about rheumatoid arthritis except what causes it and how to cure it" may still be true, but we certainly have a number of clues. This book presents the cutting edge of developments in etiology, mechanisms of inflammation, disease manifestations and management of this common, crippling disease. Therapy for RA has traditionally been with non-steroid anti-inflammatory drugs, progressing to second-line drugs, but this has not been effective in preventing erosion of bone and symptoms. Rapid advances in knowledge have led to new concepts in the mechanisms of the disease and new possibilities for treatment. This book deals with the This book is intended for clinical specialist and research rheumatologists. Immunologists working in areas of research in rheumatology.